6-Benzyl-5,6,7,8-tetrahydro-1,6-naphthyridin-2(1H)-one → 5,6,7,8-Tetrahydro-1,6-naphthyridin-2(1H)-one

Participants

Reaction Steps

To a solution of 6-benzyl-5,6,7,8-tetrahydro-1,6-naphthyridin-2(1H)-one (400 mg, 1.66 mmol) in EtOH (30 mL) is added 20% Pd(OH)2/C (20 mg) and the mixture is hydrogenated at 50 psi at rt overnight. The catalyst is filtered and the filtrate is concentrated to give the title compound as a light yellow solid. MS (M+1): 151.1

Provenance & Evidence