反应详情

温度

30 °C

To a solution of tert-butyl N-(3′-bezyloxy-biphenyl-4-ylmethyl)carbamate (1.16 g) in ethanol/tetrahydrofuran (4/1, 30 mL) was added 10% palladium-on carbon (55.4 wt % H2O, 0.520 g), and the resulting mixture was stirred at 30° C. for 5 hours under a hydrogen atmosphere. The insoluble material was filtered out and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (eluent: hexane/ethyl acetate=5/2) to give the title compound (0.731 g).

1. filtrationThe insoluble material was filtered out
2. concentrationthe filtrate was concentrated under reduced pressure
3. customThe residue was purified by column chromatography on silica gel (eluent: hexane/ethyl acetate=5/2)