Triphenylphosphine → HCID 67453620, compound

Participants

Reaction Steps

To a solution of tert-butyl N-(3′-hydroxybiphenyl-4-ylmethyl)carbamate (0.400 g), 4-benzyloxy-1-butanol (0.313 g) and triphenylphosphine (0.456 g) in tetrahydrofuran (6.7 mL) was added dropwise diisopropyl azodicarboxylate (40% toluene solution, 0.878 g), and the resulting mixture was stirred at room temperature for 75 minutes. The reaction mixture was concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (eluent: dichloromethane/ethyl acetate=6/1) to give the title compound (0.551 g).

Provenance & Evidence