Thiophenol → 2-(Phenylthio)benzaldehyde

HRID 1713276ノート

反応式

HRID 1713276 の反応式
F[C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[C:16]1([SH:22])[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>CN1CCN(C)C1=O>[C:16]1([S:22][C:8]2[CH:9]=[CH:2][CH:3]=[CH:4][C:5]=2[CH:6]=[O:7])[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

参加物

5

反応物 3

HCID 7969ThiophenolHCID 11430Potassium CarbonateHCID 680234-Fluorobenzaldehyde

生成物 1

HCID 123406852-(Phenylthio)benzaldehyde

試薬・触媒・溶媒 1

HCID 66611,3-Dimethyl-2-imidazolidinone溶媒

反応条件

温度
120 °C

実験手順

To a solution of 4-fluorobenzaldehyde (0.443 mL) in 1,3-dimethyl-2-imidazolidinone (6.4 mL) was added potassium carbonate (0.659 g). Then benzenethiol (0.326 mL) was added, and the resulting mixture was stirred at 120° C. for 2.5 hours. The reaction mixture was cooled to room temperature and then partitioned between diethyl ether (60 mL) and water (15 mL). The organic layer was washed successively with water (15 mL×2) and brine (15 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the title compound (0.826 g).

後処理

  1. temperatureThe reaction mixture was cooled to room temperature
  2. custompartitioned between diethyl ether (60 mL) and water (15 mL)
  3. washThe organic layer was washed successively with water (15 mL×2) and brine (15 mL)
  4. dry with materialdried over anhydrous sodium sulfate
  5. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-daa6ad5e427d4219b2f5d55646c4e34f
出典データセット
uspto-grants-2010_09
特許番号
US07795236B2

反応ノート

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