Lithium → HCID 67457719, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of lithium alminiumhydride (0.399 g) in tetrahydrofuran (45 mL) was added dropwise a solution of 3-benzyloxy-4-phenylbenzonitrile (2.00 g) in tetrahydrofuran (25 mL) at room temperature, and the resulting mixture was stirred at 60° C. for 3 hours. The reaction mixture was cooled to room temperature and then quenched by sequential addition of water (0.399 mL), 15% aqueous sodium hydroxide (0.399 mL) and water (0.399 mL). After addition of anhydrous sodium sulfate (20 g), the mixture was stirred at room temperature for 4 hours and the insoluble material was filtered out. The filtrate was concentrated under reduced pressure to give the title compound (1.97 g).

Provenance & Evidence