4-(Benzyloxy)-3-[4-(benzyloxy)butoxy]benzonitrile → HCID 23143889, compound

Participants

Reaction Steps

4-Benzyloxy-3-(4-benzyloxybutoxy)benzonitrile (4.0 g) was dissolved in a mixed solvent of trifluoroacetic acid (9 mL), dimethyl sulfide (0.5 mL) and water (5 mL), and the resulting mixture was stirred at room temperature for 18 hours. The reaction mixture was concentrated under reduced pressure and the residue was purified by column chromatography on silica gel (eluent: ethyl acetate/hexane=1/5) to give the title compound (1.0 g).

Provenance & Evidence