1-Bromo-3-chloropropane → HCID 67457441, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-hydroxy-4-phenylbenzonitrile (3.0 g) in N,N-dimethylformamide (30.7 mL) was added potassium carbonate (6.37 g). Then 1-bromo-3-chloropropane (3.6 mL) was added, and the resulting mixture was stirred at 50° C. for 4 hours. The reaction mixture was partitioned between diethyl ether (45 mL) and water (10 mL). The organic layer was washed with water (10 mL×2) and brine (10 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (eluent: hexane/ethyl acetate=15/1) to give the title compound (4.08 g).

Provenance & Evidence