Phthalimide → HCID 67458000, compound

Participants

Reaction Steps

[3′-(4-Benzyloxycarbonylaminobutyl)biphenyl-4-yl]-methanol (0.40 g) was dissolved in tetrahydrofuran (4.1 mL). After addition of phthalimide (0.14 g) and triphenylphosphine (0.26 g) were added, diisopropyl azodicarboxylate (40% toluene solution, 0.5 g) was added dropwise, and the resulting mixture was stirred at room temperature for 6 hours. The reaction mixture was concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (eluent: hexane/ethyl acetate=2/1) to give the title compound (0.4 g)

Provenance & Evidence