1-Bromo-3-chloropropane → HCID 67456356, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2′,3′,5′-tris-O-(tert-butyl-dimethylsilyl)-8-(2-hydroxybiphenyl-4-ylmethylamino)-adenosine (0.85 g) in N,N-dimethylformamide (5.3 mL) was added potassium carbonate (0.44 g). Then 1-bromo-3-chloropropane (0.16 mL) was added, and the resulting mixture was stirred at 40° C. for 42 hours. The reaction mixture was partitioned between diethyl ether (45 mL) and water (10 mL). The organic layer was washed successively with water (10 mL×2), and brine (10 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the title compound (0.91 g).

Provenance & Evidence