Ammonia methanol → HCID 59460397, compound

HRID 1713329Notes

Reaction equation

C[O:2][C:3]([CH2:5][O:6][C:7]1[CH:8]=[C:9]([C:13]2[CH:18]=[CH:17][C:16]([CH2:19][NH:20][C:21]3[N:22]([C:32]4[N:33]=[CH:34][N:35]=[C:36]([NH2:39])[C:37]=4[N:38]=3)[C@@H:23]3[O:31][C@H:28]([CH2:29][OH:30])[C@@H:26]([OH:27])[C@H:24]3[OH:25])=[CH:15][CH:14]=2)[CH:10]=[CH:11][CH:12]=1)=O.CO.[NH3:42]>>[C:3]([CH2:5][O:6][C:7]1[CH:8]=[C:9]([C:13]2[CH:18]=[CH:17][C:16]([CH2:19][NH:20][C:21]3[N:22]([C:32]4[N:33]=[CH:34][N:35]=[C:36]([NH2:39])[C:37]=4[N:38]=3)[C@@H:23]3[O:31][C@H:28]([CH2:29][OH:30])[C@@H:26]([OH:27])[C@H:24]3[OH:25])=[CH:15][CH:14]=2)[CH:10]=[CH:11][CH:12]=1)(=[O:2])[NH2:42]

Participants

Reactant 2

HCID 21705897Ammonia methanol

HCID 59460371HCID 59460371, compound

Product 1

HCID 59460397HCID 59460397, compound

Procedure

8-(3′-Methoxycarbonylmethoxybiphenyl-4-ylmethyl-amino)adenosine (0.080 g) was dissolved in 2.0 M ammonia methanol solution (3.0 mL), and the resulting mixture was stirred at room temperature for 18 hours. The reaction mixture was concentrated under reduced pressure to give the title compound (0.080 g).

Workup

concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record: ord-643523eb82724dc4b1c2833a59e6f459
Source dataset: uspto-grants-2010_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07795236B2

Reaction notes

Loading…