Sodium Hydroxide → HCID 67455120, compound

Participants

Reaction Steps

To a solution of 8-[3-(4-ethoxycarbonylbutoxy)-biphenyl-4-ylmethylamino]adenosine (0.077 g) in methanol (1.3 mL) was added 2 mol/L aqueous sodium hydroxide (0.098 mL), and the resulting mixture was stirred at room temperature for 21 hours and then at 50° C. for 2 hours. Two mol/L aqueous sodium hydroxide (0.098 mL) was added and stirring was continued for additional 64 hours. The reaction mixture was cooled to room temperature, quenched by addition of 2 mol/L hydrochloric acid (0.227 mL) and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (eluent: dichloromethane/methanol=4/1) to give the title compound (0.083 g).

Provenance & Evidence