Water → HCID 11750725, compound

Participants

Reaction Steps

1-(2-hydroxy-ethoxymethyl)uracil (0.50 g, 2.69 mmol) and triphenylmethyl chloride (0.82 g, 2.96 mmol) were stirred in dry pyridine (20 ml) overnight at 50° C. under an atmosphere of nitrogen. H2O (10 ml) was added and the mixture was extracted with CHCl3 (2×50 ml), dried (Na2SO4) and reduced in vacuo to obtain a crude product, which was purified by column chromatography eluting with 0→3% MeOH/CHCl3 to obtain the title compound as a white solid (0.23 g, 20%).

Provenance & Evidence