HRID1713389

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID20119694

未命名化合物

HCID86625117

未命名化合物

PRODUCTS

生成物

结构：Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1NC(=O)c1cnn2cc(S(=O)(=O)N(C)C)ccc12

HCID16662084

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID1049

Pyridine

C5H5N

PROCEDURE

实验过程

6-Dimethylsulfamoyl-pyrazolo[1,5-a]pyridine-3-carbonyl chloride (200 mg, 0.35 mmol) and 3-amino-4-methyl-N-(3-trifluoromethyl-phenyl)-benzamide are reacted in 2 ml dry pyridine at r.t. for 18 hrs. The solvent is removed under reduced pressure. The product is isolated by automated column chromatography and is dried at the high vacuum pump, yielding the title compound as a white solid.

WORKUP

后处理

customThe solvent is removed under reduced pressure
customThe product is isolated by automated column chromatography
customis dried at the high vacuum pump

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3ef696b5e4514f45914c00dc16067d8a
来源数据集: uspto-grants-2010_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07795273B2
来源说明: uspto-grants-2010_09

反应 SMILES

[CH3:1][N:2]([CH3:18])[S:3]([C:6]1[CH:7]=[CH:8][C:9]2[N:10]([N:12]=[CH:13][C:14]=2[C:15](Cl)=[O:16])[CH:11]=1)(=[O:5])=[O:4].[NH2:19][C:20]1[CH:21]=[C:22]([CH:36]=[CH:37][C:38]=1[CH3:39])[C:23]([NH:25][C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([C:32]([F:35])([F:34])[F:33])[CH:27]=1)=[O:24]>N1C=CC=CC=1>[CH3:39][C:38]1[CH:37]=[CH:36][C:22]([C:23](=[O:24])[NH:25][C:26]2[CH:31]=[CH:30][CH:29]=[C:28]([C:32]([F:33])([F:34])[F:35])[CH:27]=2)=[CH:21][C:20]=1[NH:19][C:15]([C:14]1[CH:13]=[N:12][N:10]2[CH:11]=[C:6]([S:3](=[O:5])(=[O:4])[N:2]([CH3:18])[CH3:1])[CH:7]=[CH:8][C:9]=12)=[O:16]