HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 3-Methyl-1,2-dihydroisoquinolin-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 4-hydroxy-3-methyl-2H-isoquinolin-1-one | HCID 224567 | — |
| Solvent | Hydrogen iodide | HCID 24841 | — |
| Product | 3-Methyl-1,2-dihydroisoquinolin-1-one | HCID 3244477 | 46% |
Reaction Steps
24.6 g (140 mmol) of 4-hydroxy-3-methyl-2H-isoquinolin-1-one are heated together with 9.13 g (294 mmol) of red phosphorus in 55% hydriodic acid (130 ml) at 160° C. for 7 days. The cooled mixture is poured into water and extracted with dichloromethane. 10.2 g (46% yield) of a white solid are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07795278B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-c6fe089fc4034bf78dbfc9309990ef97 |
| Source note | uspto-grants-2010_09 |