Methyl iodide → HCID 59463805, compound

Participants

Reaction Conditions

Reaction Steps

8.9 g (36.8 mmol) of 4-bromo-3-methyl-5,6,7,8-tetrahydro-2H-isoquinolin-1-one are dissolved in 200 ml of chloroform and, after addition of 13.7 g (49.6 mmol) of silver(I) carbonate and 16.2 ml (36.5 g, 257 mmol) of methyl iodide, stirred at 50° C. for 3 h. After a further 24 h at RT, the suspension is filtered through Celite, concentrated and chromatographed on silica gel using n-heptane with addition of 2% ethyl acetate. A colorless oil (7.8 g, 83% yield) is obtained.

Provenance & Evidence