Trimethylsilyl iodide → HCID 59463816, compound

Participants

Reaction Steps

560 mg (1.7 mmol) of ethyl 3-(1-methoxy-5,6,7,8-tetrahydroisoquinolin-4-ylamino)benzoate (compound 12) are dissolved in 30 ml of chloroform and, at room temperature, 413 mg (2.1 mmol) of trimethylsilyl iodide are added. The mixture is then heated to reflux until complete conversion is reached by means of LCMS. Further trimethylsilyl iodide is added if necessary. For workup, the mixture is washed twice with H2O, dried with Na2SO4 and concentrated. Chromatography on silica gel (CH2Cl2/MeOH 95:5) affords 216 mg of the title compound. Yield: 40%.

Provenance & Evidence