Water → HCID 59463859, compound

Participants

Reaction Conditions

Reaction Steps

To a cooled (0° C.) suspension of 1-(3,5-Difluoro-benzyl)-3-(2-nitro-phenylsulfanyl)-1H-indole-6-carboxylic acid amide (15 mg, 0.034 mmol) and Et3N (10 μL, 0.072 mmol) in CH2Cl2 (1.5 mL) was added Tf2O (13 μL, 0.077 mmol). The mixture was stirred at 0° C. for 2 h and then at room temperature for 20 h. Water (25 mL) was added and the mixture was extracted with CH2Cl2 (2×25 mL). The combined organic phases were dried (Na2SO4) and concentrated to give the title compound as a yellow solid (13 mg, yield: 91%).

Provenance & Evidence