HCID 23121865, compound → 1,1-Dimethylhexahydro-3H-[1,3]oxazolo[3,4-a]pyrazin-3-one

HRID 1713481Notes

Reaction equation

HRID 1713481 reaction equation
C1(COC([N:11]2[CH2:16][CH2:15][N:14]3[C:17](=[O:22])[O:18][C:19]([CH3:21])([CH3:20])[CH:13]3[CH2:12]2)=O)C=CC=CC=1>C(O)C.[C].[Pd]>[CH3:20][C:19]1([CH3:21])[CH:13]2[CH2:12][NH:11][CH2:16][CH2:15][N:14]2[C:17](=[O:22])[O:18]1

Participants

4

Reactant 1

HCID 23121865HCID 23121865, compound

Product 1

HCID 231220551,1-Dimethylhexahydro-3H-[1,3]oxazolo[3,4-a]pyrazin-3-oneYield 73%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

(Phenylmethyl)tetrahydro-3-oxo-1,1-dimethyl-3H-oxazolo[3,4-a]pyrazine-7(1H)-carboxylate (0.97 g, 3.2 mmol) was dissolved in ethanol (50 mL). 10% Palladium carbon (0.10 g) was added thereto, and the resulting mixture was stirred under hydrogen atmosphere at room temperature one whole day and night. The reaction solution was filtered through a Celite, and the Celite was washed with ethanol. The filtrate was concentrated under reduced pressure and left to stand at room temperature overnight. The resulting crystals were collected by filtration and washed with diethyl ether to obtain the title compound (0.39 g, yield 73%).

Workup

  1. filtrationThe reaction solution was filtered through a Celite
  2. washthe Celite was washed with ethanol
  3. concentrationThe filtrate was concentrated under reduced pressure
  4. waitleft
  5. filtrationThe resulting crystals were collected by filtration
  6. washwashed with diethyl ether

Sources & evidence

ORD record
ord-3f31592aff7540e3aa26d3a94fc354f5
Source dataset
uspto-grants-2010_09
Patent number
US07795267B2

Reaction notes

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