Hydrogen chloride-ethyl acetate → HCID 23121933, compound

Participants

Reaction Steps

To a solution of hexahydro-1,1-dicyclohexyl-7-(triphenylmethyl)-3H-oxazolo[3,4-a]pyrazin-3-one (0.92 g, 1.7 mmol) in tetrahydrofuran (5 mL) was added a 4 M hydrogen chloride/ethyl acetate solution (5 mL) with ice cooling, and the mixture was stirred at room temperature for 2.5 hours. The reaction solution was concentrated under reduced pressure, water was then added thereto and washed with diethyl ether. To the aqueous layer was added sodium hydrogen carbonate, and the mixture was adjusted to pH 7 and then extracted with ethyl acetate. The extract was washed with water and concentrated under reduced pressure. The precipitated crystals were washed with hexane and dried to obtain the title compound (0.41 g, yield 80%).

Provenance & Evidence