HCID 23121976, compound → HCID 23122075, compound

HRID 1713489Notes

Reaction equation

HRID 1713489 reaction equation
[C:1]1([CH2:7][C:8]([CH2:30][C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)([CH:10]2[CH2:15][N:14](CC3C=CC=CC=3)[CH2:13][CH2:12][N:11]2CC2C=CC=CC=2)[OH:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>C(O)C.O.[C].[Pd]>[C:1]1([CH2:7][C:8]([CH2:30][C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)([CH:10]2[CH2:15][NH:14][CH2:13][CH2:12][NH:11]2)[OH:9])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 1

HCID 23121976HCID 23121976, compound

Product 1

HCID 23122075HCID 23122075, compoundYield 94.5%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 19096565Water ethanolSolvent

Procedure

α,α,1,4-Tetrakis(phenylmethyl)-2-piperazinemethanol (4.9 g, 10 mmol) was dissolved in ethanol/water (100 mL/5 mL). 10% Palladium carbon (0.49 g) was added thereto, and the mixture was stirred under hydrogen pressure (3.0 bar) at room temperature one whole day and night. The reaction system was filtered through a Celite, the Celite was washed with ethanol, and then the filtrate was concentrated under reduced pressure. The resulting crystals were washed with diethyl ether to obtain the title compound (2.8 g, yield 91%).

Workup

  1. filtrationThe reaction system was filtered through a Celite
  2. washthe Celite was washed with ethanol
  3. concentrationthe filtrate was concentrated under reduced pressure
  4. washThe resulting crystals were washed with diethyl ether

Sources & evidence

ORD record
ord-e4e6803cf6af4efd80e73213fa68262e
Source dataset
uspto-grants-2010_09
Patent number
US07795267B2

Reaction notes

Loading…