2-Chlorobenzoxazole → HCID 23121962, compound

Participants

Reaction Steps

To a solution of hexahydro-1,1-diphenyl-3H-oxazolo[3,4-a]pyrazin-3-one (60 mg, 0.2 mmol) in tetrahydrofuran (2 mL) were sequentially added diisopropylethylamine (0.3 mL) and 2-chlorobenzoxazole (45 mg, 0.29 mmol), and the mixture was stirred at room temperature for 3 hours. The reaction solution was concentrated under reduced pressure. Then, the residue was purified with silica gel column chromatography (hexane:ethyl acetate=3:1) and recrystallized from diisopropyl ether to obtain the title compound (51 mg, yield 62%).

Provenance & Evidence