Phenyl isocyanate → HCID 23121998, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of hexahydro-1,1-diphenyl-3H-oxazolo[3,4-a]pyrazin-3-one (85 mg, 0.29 mmol) in toluene (3 mL) was added phenyl isocyanate (70 mg, 0.59 mmol), and the mixture was stirred at 60° C. for 4 hours. The reaction solution was concentrated. Then, the residue was purified with silica gel column chromatography (hexane:ethyl acetate=2:1) and crystallized from diisopropyl ether to obtain the title compound (0.12 g, yield 99%).

Provenance & Evidence