Benzoic Acid → Benzophenone

Participants

Reaction Steps

Methoxyaryl 1 h can be coupled with benzoyl chloride 2h, either commercially available or prepared in situ from the corresponding benzoic acid, using a Lewis acid, typically AlCl3 or the like, to give benzophenone product 3h. Reduction of 3h can be accomplished by triethylsilane and an appropriate protic or Lewis acid, typically trifluoroacetic acid or borontrifluoroetherate, to give arylbenzyl 4h.

Provenance & Evidence