3,5-Difluoro-L-phenylalanine → HCID 68510986, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 1.6 g of (S)-3,5-difluoro-phenyalanine in 5.3 ml of H2SO4 (2.5N) is admixed dropwise at 0° C. with a solution of 0.829 g of sodium nitrite in 4.2 ml of H2O. The reaction mixture is stirred for 2 hours at 0° C. and then for 17 hours at ambient temperature. The reaction mixture is extracted with 2×100 ml of AcOEt. The combined organic phases are washed with 100 ml of saturated NaCl solution in H2O. Drying gives 1.197 g of yellow crystals. The acid obtained is used without further purification in the following step.

Provenance & Evidence