[5-(4-Methoxy-phenyl)-thiazol-2-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine → [5-(4-Methoxy-phenyl)-thiazol-2-yl]-[4-(4-methyl-piperazin-1-yl)-phenyl]-amine

참여 물질

역할	이름	HCID	투입량
반응물	[5-(4-Methoxy-phenyl)-thiazol-2-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine	HCID 11188635	—
반응물	[4-(4-Methylpiperazin-1-yl)phenyl]thiourea	HCID 39146979	—
생성물	[5-(4-Methoxy-phenyl)-thiazol-2-yl]-[4-(4-methyl-piperazin-1-yl)-phenyl]-amine	HCID 11773416	—

반응 단계

The title compound is prepared as described in Example 3 for [5-(4-methoxy-phenyl)-thiazol-2-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine but using [4-(4-methyl-piperazin-1-yl)-phenyl]-thiourea. Purification of the crude product by silica gel (20 g) column chromatography (CH2Cl2/MeOH, 90/10) and subsequent washing of the purified product with MeOH affords the title compound as a light beige solid: ES-MS: 381.0 [M+H]+; single peak at tR=6.13 min (System 1); Rf=0.53 (CH2Cl2/MeOH, 80/20).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07795288B2
출처 데이터셋	uspto-grants-2010_09
ORD ID	ord-b2d2e76060e14a2caed39a8b6f4863bc
출처 메모	uspto-grants-2010_09