4-(4-Methylpiperazin-1-yl)aniline → 1-(4-Isothiocyanatophenyl)-4-methylpiperazine

HRID 1713641Notes

Reaction equation

HRID 1713641 reaction equation
[N:1]([C:4]1[CH:17]=[CH:16][C:7](OCCN2CCCC2)=[CH:6][CH:5]=1)=[C:2]=[S:3].[CH3:18][N:19]1[CH2:24][CH2:23][N:22](C2C=CC(N)=CC=2)[CH2:21][CH2:20]1>>[N:1]([C:4]1[CH:5]=[CH:6][C:7]([N:22]2[CH2:23][CH2:24][N:19]([CH3:18])[CH2:20][CH2:21]2)=[CH:16][CH:17]=1)=[C:2]=[S:3]

Participants

3

Reactant 2

HCID 7372534-(4-Methylpiperazin-1-yl)anilineHCID 118461221-(2-(4-Isothiocyanatophenoxy)ethyl)pyrrolidine

Product 1

HCID 137183971-(4-Isothiocyanatophenyl)-4-methylpiperazine

Procedure

The title compound is prepared as described in Example 1 for 1-[2-(4-isothiocyanato-phenoxy)-ethyl]-pyrrolidine but using 4-(4-methyl-piperazin-1-yl)-phenylamine. Title compound: ES-MS: 234.0 [M+H]+; single peak at tR=6.60 min (System 1).

Workup

  1. customThe title compound is prepared

Sources & evidence

ORD record
ord-8964d51a763949d59a6ebb703185b2e4
Source dataset
uspto-grants-2010_09
Patent number
US07795288B2

Reaction notes

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