HuagongsheHuagongshe Chemistry Print Report · For research reference only
[5-(4-Methoxy-phenyl)-thiazol-2-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine → [4-(2-Dimethylamino-ethoxy)-phenyl]-[5-(4-methoxy-phenyl)thiazol-2-yl]-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | [5-(4-Methoxy-phenyl)-thiazol-2-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine | HCID 11188635 | — |
| Reactant | 1-(4-(2-(Dimethylamino)ethoxy)phenyl)thiourea | HCID 58923531 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | [4-(2-Dimethylamino-ethoxy)-phenyl]-[5-(4-methoxy-phenyl)thiazol-2-yl]-amine | HCID 11199508 | — |
Reaction Steps
The title compound is prepared as described in Example 3 for [5-(4-methoxy-phenyl)-thiazol-2-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine but using [4-(2-dimethylamino-ethoxy)-phenyl]-thiourea. Title compound: ES-MS: 370.0 [M+H]+; single peak at tR=6.13 min (System 1); Rf=0.13 (CH2Cl2/MeOH, 80/20).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07795288B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-39be58d0ddf547e299b0a74550c1c6be |
| Source note | uspto-grants-2010_09 |