4-[2-(Dimethylamino)ethoxy]phenyl isothiocyanate → 1-(4-(2-(Dimethylamino)ethoxy)phenyl)thiourea

HRID 1713643Notes

Reaction equation

HRID 1713643 reaction equation
[N:1]1([CH2:6][CH2:7][O:8][C:9]2[CH:14]=[CH:13][C:12]([NH:15][C:16]([NH2:18])=O)=[CH:11][CH:10]=2)[CH2:5]CC[CH2:2]1.N(C1C=CC(OCCN(C)C)=CC=1)=C=[S:21]>>[CH3:2][N:1]([CH3:5])[CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([NH:15][C:16]([NH2:18])=[S:21])=[CH:11][CH:10]=1

Participants

3

Reactant 2

HCID 226409714-[2-(Dimethylamino)ethoxy]phenyl isothiocyanateHCID 68704441[4-(2-Pyrrolidin-1-yl-ethoxy)-phenyl]-urea

Product 1

HCID 589235311-(4-(2-(Dimethylamino)ethoxy)phenyl)thiourea

Procedure

The title compound is prepared as described in Example 1 for [4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-urea but using [2-(4-isothiocyanato-phenoxy)-ethyl]-dimethyl-amine. The title compound: ES-MS: 240.0 [M+H]+; single peak at tR=3.52 min (System 1).

Workup

  1. customThe title compound is prepared

Sources & evidence

ORD record
ord-97df8a19cc0440d49869b2b66c4dd06e
Source dataset
uspto-grants-2010_09
Patent number
US07795288B2

Reaction notes

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