4-[2-(Dimethylamino)ethoxy]aniline → 4-[2-(Dimethylamino)ethoxy]phenyl isothiocyanate

HRID 1713644Notes

Reaction equation

HRID 1713644 reaction equation
[N:1]([C:4]1[CH:17]=[CH:16][C:7]([O:8][CH2:9][CH2:10][N:11]2[CH2:15]CC[CH2:12]2)=[CH:6][CH:5]=1)=[C:2]=[S:3].CN(C)CCOC1C=CC(N)=CC=1>>[N:1]([C:4]1[CH:17]=[CH:16][C:7]([O:8][CH2:9][CH2:10][N:11]([CH3:12])[CH3:15])=[CH:6][CH:5]=1)=[C:2]=[S:3]

Participants

3

Reactant 2

HCID 64846554-[2-(Dimethylamino)ethoxy]anilineHCID 118461221-(2-(4-Isothiocyanatophenoxy)ethyl)pyrrolidine

Product 1

HCID 226409714-[2-(Dimethylamino)ethoxy]phenyl isothiocyanate

Procedure

The title compound is prepared as described in Example 1 for 1-[2-(4-isothiocyanato-phenoxy)-ethyl]-pyrrolidine but using 4-(2-dimethylamino-ethoxy)-phenylamine. Title compound: ES-MS: 223.0 [M+H]+; single peak at tR=6.52 min (System 1).

Workup

  1. customThe title compound is prepared

Sources & evidence

ORD record
ord-8b713d8af6ac4436ab02905195213fb9
Source dataset
uspto-grants-2010_09
Patent number
US07795288B2

Reaction notes

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