Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Boron tribromide → 4-(2-Phenylamino-thiazol-5-yl)-phenol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Boron tribromide | HCID 25134 | — |
| 반응물 | 4-{2-[4-(2-Pyrrolidin-1-yl-ethoxy)-phenylamino]-thiazol-5-yl}-phenol | HCID 11188206 | — |
| 반응물 | [5-(4-Methoxy-phenyl)-thiazol-2-yl]-phenyl-amine | HCID 58923516 | — |
| 용매 | Dichloromethane methanol | HCID 21226129 | — |
| 생성물 | 4-(2-Phenylamino-thiazol-5-yl)-phenol | HCID 58923536 | — |
반응 단계
The title compound is prepared as described in Example 7 for 4-{2-[4-(2-pyrrolidin-1-yl-ethoxy)-phenylamino]-thiazol-5-yl}-phenol but starting from [5-(4-methoxy-phenyl)-thiazol-2-yl]-phenyl-amine and using 2 equivalents of BBr3. Title compound: ES-MS: 269.0 [M+H]+; single peak at tR=6.65 min (System 1); Rf=0.05 (CH2Cl2/MeOH, 98/2).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07795288B2 |
| 출처 데이터셋 | uspto-grants-2010_09 |
| ORD ID | ord-5129ac82db3047d6aebf25bee26a5146 |
| 출처 메모 | uspto-grants-2010_09 |