HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloroethyldiisopropylammonium chloride → [4-(2-Diisopropylamino-ethoxy)-phenyl]-(5-thiophen-3-yl-thiazol-2-yl)-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloroethyldiisopropylammonium chloride | HCID 77942 | — |
| Reactant | {5-[4-(3-Dimethylamino-propoxy)-phenyl]-thiazol-2-yl}phenyl-amine | HCID 11245147 | — |
| Reactant | 4-(5-Thiophen-3-yl-thiazol-2-yl-amino)-phenol | HCID 11288835 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | [4-(2-Diisopropylamino-ethoxy)-phenyl]-(5-thiophen-3-yl-thiazol-2-yl)-amine | HCID 11361632 | — |
Reaction Steps
The title compound is prepared as described in Example 8 for {5-[4-(3-dimethylamino-propoxy)-phenyl]-thiazol-2-yl}-phenyl-amine but starting from 4-(5-thiophen-3-yl-thiazol-2-yl-amino)-phenol (Example 12) and using (2-chloroethyl)-diisopropyl-amine hydrochloride. Title compound: ES-MS: 402.0 [M+H]+; single peak at tR=6.53 min (System 1); Rf=0.50 (CH2Cl2/MeOH, 80/20).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07795288B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-07251555734a4abf98837b4a08ddaf5f |
| Source note | uspto-grants-2010_09 |