HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrrolidine, 2-(2-chloroethyl)-1-methyl-, hydrochloride (1:1) → HCID 58923525, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrrolidine, 2-(2-chloroethyl)-1-methyl-, hydrochloride (1:1) | HCID 3017050 | — |
| Reactant | {5-[4-(3-Dimethylamino-propoxy)-phenyl]-thiazol-2-yl}phenyl-amine | HCID 11245147 | — |
| Reactant | 4-(5-Thiophen-3-yl-thiazol-2-yl-amino)-phenol | HCID 11288835 | — |
| Product | HCID 58923525 | HCID 58923525 | — |
Reaction Steps
The title compound is prepared as described in Example 8 for {5-[4-(3-dimethylamino-propoxy)-phenyl]-thiazol-2-yl}-phenyl-amine but starting from 4-(5-thiophen-3-yl-thiazol-2-yl-amino)-phenol (Example 12) and using 2-(2-chloroethyl)-1-methylpyrrolidine hydrochloride. MPLC (CH3CN/H2O/TFA) purification affords the title compound: ES-MS: 386.0 [M+H]+; single peak at tR=3.09 min (System 2).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07795288B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-605562d3a4bd4dcd8fe1476568a97830 |
| Source note | uspto-grants-2010_09 |