HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1713664Generated: October 30, 2026
1-Chloro-2-(diethylamine)ethane hydrochloride → HCID 58923533, compound
https://huagongshe.com/reaction/1713664
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Chloro-2-(diethylamine)ethane hydrochloride | HCID 13363 | — |
| Reactant | {5-[4-(3-Dimethylamino-propoxy)-phenyl]-thiazol-2-yl}phenyl-amine | HCID 11245147 | — |
| Reactant | HCID 58923529 | HCID 58923529 | — |
| Product | HCID 58923533 | HCID 58923533 | — |
Reaction Steps
The title compound is prepared as described in Example 8 for {5-[4-(3-dimethylamino-propoxy)-phenyl]-thiazol-2-yl}-phenyl-amine but starting from 4-[5-(3-bromo-phenyl)-thiazol-2-ylamino]-phenol and using (2-chloroethyl)-diethylamine hydrochloride. After stirring the reaction mixture for 30 min at 70° C., purification of the crude material by silica gel column chromatography (CH2Cl2/MeOH, 95/5 then 90/10) affords the title compound: ES-MS: 447.9 [M+2]+; single peak at tR=3.77 min (System 2); Rf=0.14 (CH2Cl2/MeOH, 90/10).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07795288B2 |
|---|
| Source dataset | uspto-grants-2010_09 |
|---|
| ORD ID | ord-1f0a85246b46456ab6f8f40e00bba02f |
|---|
| Source note | uspto-grants-2010_09 |
|---|
