4-(5-Thiophen-3-yl-thiazol-2-yl-amino)-phenol → HCID 58923529, compound

HRID 1713665Notes

Reaction equation

HRID 1713665 reaction equation
S1[CH:5]=[CH:4][C:3]([C:6]2[S:10][C:9]([NH:11][C:12]3[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][CH:13]=3)=[N:8][CH:7]=2)=[CH:2]1.[Br:19][C:20]1C=C(CC=O)C=C[CH:25]=1>C(Cl)Cl.CO>[Br:19][C:20]1[CH:2]=[C:3]([C:6]2[S:10][C:9]([NH:11][C:12]3[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][CH:13]=3)=[N:8][CH:7]=2)[CH:4]=[CH:5][CH:25]=1

Participants

4

Reactant 2

HCID 112888354-(5-Thiophen-3-yl-thiazol-2-yl-amino)-phenolHCID 20387554(3-Bromophenyl)acetaldehyde

Product 1

HCID 58923529HCID 58923529, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound is prepared as described in Example 12 (Procedure B) for 4-(5-thiophen-3-yl-thiazol-2-yl-amino)-phenol but starting from (3-bromophenyl)-acetaldehyde. The title compound: ES-MS: 348.9 [M+2]+; single peak at tR=3.92 min (System 2); Rf=0.47 (CH2Cl2/MeOH, 90/10).

Workup

  1. customThe title compound is prepared

Sources & evidence

ORD record
ord-3070ef6968ed46eebd2841b72d833026
Source dataset
uspto-grants-2010_09
Patent number
US07795288B2

Reaction notes

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