HuagongsheHuagongshe Chemistry Print Report · For research reference only
{5-[4-(3-Dimethylamino-propoxy)-phenyl]-thiazol-2-yl}phenyl-amine → [5-(2-Chloro-phenyl)-thiazol-2-yl]-[4-(2-diethylamino-ethoxy)-phenyl]-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | {5-[4-(3-Dimethylamino-propoxy)-phenyl]-thiazol-2-yl}phenyl-amine | HCID 11245147 | — |
| Reactant | N,N-Dimethylaminoethyl chloride hydrochloride | HCID 11636816 | — |
| Reactant | Dichloromethane methanol | HCID 21226129 | — |
| Reactant | 4-[5-(2-Chloro-phenyl)-thiazol-2-ylamino]-phenol | HCID 58923528 | — |
| Product | [5-(2-Chloro-phenyl)-thiazol-2-yl]-[4-(2-diethylamino-ethoxy)-phenyl]-amine | HCID 86613640 | — |
Reaction Steps
The title compound is prepared as described in Example 8 for {5-[4-(3-dimethylamino-propoxy)-phenyl]-thiazol-2-yl}-phenyl-amine but starting from 4-[5-(2-chloro-phenyl)-thiazol-2-ylamino]-phenol and using (2-chloroethyl)-dimethylamine hydrochloride. The title compound: ES-MS: 374.0 [M+H]+; single peak at tR=3.17 min (System 2); Rf=0.23 (CH2Cl2/MeOH, 90/10).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07795288B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-5a0afbb972d646aaa505c484b06125b3 |
| Source note | uspto-grants-2010_09 |