HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Chloro-2-(diethylamine)ethane hydrochloride → [4-(2-Diethylamino-ethoxy)-phenyl]-[5-(3-thiophen-3-yl-phenyl)-thiazol-2-yl]-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Chloro-2-(diethylamine)ethane hydrochloride | HCID 13363 | — |
| Reactant | {5-[4-(3-Dimethylamino-propoxy)-phenyl]-thiazol-2-yl}phenyl-amine | HCID 11245147 | — |
| Reactant | 4-[5-(3-Thiophen-3-yl-phenyl)-thiazol-2-ylamino]-phenol | HCID 58923506 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | [4-(2-Diethylamino-ethoxy)-phenyl]-[5-(3-thiophen-3-yl-phenyl)-thiazol-2-yl]-amine | HCID 58923510 | — |
Reaction Steps
The title compound is prepared as described in Example 8 for {5-[4-(3-dimethylamino-propoxy)-phenyl]-thiazol-2-yl}-phenyl-amine but starting from 4-[5-(3-thiophen-3-yl-phenyl)-thiazol-2-ylamino]-phenol and using (2-chloroethyl)-diethylamine hydrochloride. The title compound: ES-MS: 450.0 [M+H]+; single peak at tR=3.98 min (System 2); Rf=0.14 (CH2Cl2/MeOH, 90/10).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07795288B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-5d6c127422b74d77809f49ea1981ec2f |
| Source note | uspto-grants-2010_09 |