HuagongsheHuagongshe Chemistry Print Report · For research reference only
{5-[4-(3-Dimethylamino-propoxy)-phenyl]-thiazol-2-yl}phenyl-amine → [4-(2-Dimethylamino-ethoxy)-2-methyl-phenyl]-(5-thiophen-3-yl-thiazol-2-yl)-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | {5-[4-(3-Dimethylamino-propoxy)-phenyl]-thiazol-2-yl}phenyl-amine | HCID 11245147 | — |
| Reactant | N,N-Dimethylaminoethyl chloride hydrochloride | HCID 11636816 | — |
| Reactant | 3-Methyl-4-(5-thiophen-3-yl-thiazol-2-ylamino)-phenol | HCID 58923508 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | [4-(2-Dimethylamino-ethoxy)-2-methyl-phenyl]-(5-thiophen-3-yl-thiazol-2-yl)-amine | HCID 58923524 | — |
Reaction Steps
The title compound is prepared as described in Example 8 for {5-[4-(3-dimethylamino-propoxy)-phenyl]-thiazol-2-yl}-phenyl-amine but starting from 3-methyl-4-(5-thiophen-3-yl-thiazol-2-ylamino)-phenol and using (2-chloroethyl)-dimethylamine hydrochloride. The title compound: ES-MS: 360.0 [M+H]+; single peak at tR=2.78 min (System 2); Rf=0.32 (CH2Cl2/MeOH, 75/25).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07795288B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-5b45d0e692ab475c9d0b0539857f380c |
| Source note | uspto-grants-2010_09 |