4-Methoxy-2-methylphenyl isothiocyanate → (4-Methoxy-2-methylphenyl)thiourea

HRID 1713678Notes

Reaction equation

HRID 1713678 reaction equation
[N:1]1(CCOC2C=CC(NC(N)=O)=CC=2)CCCC1.[N:19]([C:22]1[CH:27]=[CH:26][C:25]([O:28][CH3:29])=[CH:24][C:23]=1[CH3:30])=[C:20]=[S:21]>>[CH3:29][O:28][C:25]1[CH:26]=[CH:27][C:22]([NH:19][C:20]([NH2:1])=[S:21])=[C:23]([CH3:30])[CH:24]=1

Participants

3

Reactant 2

HCID 1424054-Methoxy-2-methylphenyl isothiocyanateHCID 68704441[4-(2-Pyrrolidin-1-yl-ethoxy)-phenyl]-urea

Product 1

HCID 20481024(4-Methoxy-2-methylphenyl)thiourea

Procedure

The title compound is prepared as described in Example 1 for [4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-urea but using 1-isothiocyanato-4-methoxy-2-methyl-benzene. Title compound: ES-MS: 196.9 [M+H]+; single peak at tR=2.46 min (System 2).

Workup

  1. customThe title compound is prepared

Sources & evidence

ORD record
ord-e9bf9b9eb94542eba01b82707c094123
Source dataset
uspto-grants-2010_09
Patent number
US07795288B2

Reaction notes

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