1-(2-(4-Isothiocyanatophenoxy)ethyl)pyrrolidine → 1-Isothiocyanato-4-methoxy-2-trifluoromethyl-benzene

HRID 1713683Notes

Reaction equation

HRID 1713683 reaction equation
[N:1]([C:4]1[CH:17]=[CH:16][C:7]([O:8][CH2:9]CN2CCCC2)=[CH:6][CH:5]=1)=[C:2]=[S:3].COC1C=CC(N)=C([C:27]([F:30])([F:29])[F:28])C=1>>[N:1]([C:4]1[CH:5]=[CH:6][C:7]([O:8][CH3:9])=[CH:16][C:17]=1[C:27]([F:30])([F:29])[F:28])=[C:2]=[S:3]

Participants

3

Reactant 2

HCID 118461221-(2-(4-Isothiocyanatophenoxy)ethyl)pyrrolidineHCID 226017214-Methoxy-2-(trifluoromethyl)aniline

Product 1

HCID 589235271-Isothiocyanato-4-methoxy-2-trifluoromethyl-benzene

Procedure

The title compound is prepared as described in Example 1 for 1-[2-(4-isothiocyanato-phenoxy)-ethyl]-pyrrolidine but using 4-methoxy-2-trifluoromethylaniline. Title compound: 1H NMR [400 MHz, (CD3)2SO]: 7.70-7.55 (m, 1H), 7.35-7.15 (m, 2H), 3.28 (s, 3H); single peak at tR=5.61 min (System 2).

Workup

  1. customThe title compound is prepared

Sources & evidence

ORD record
ord-690148b9b2544d8bb133375b96b20200
Source dataset
uspto-grants-2010_09
Patent number
US07795288B2

Reaction notes

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