HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1713691Generated: November 3, 2026
3-(Dimethylamino)propyl chloride hydrochloride → 4-(3-(Dimethylamino)propoxy)aniline
https://huagongshe.com/reaction/1713691
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-(Dimethylamino)propyl chloride hydrochloride | HCID 94308 | — |
| Reactant | 4-(2-(Pyrrolidin-1-yl)ethoxy)aniline | HCID 6493749 | — |
| Product | 4-(3-(Dimethylamino)propoxy)aniline | HCID 10058469 | — |
Reaction Steps
The title compound is prepared as described in Example 1 for 4-(2-pyrrolidin-1-yl-ethoxy)-phenylamine but using 1-chloro-3-dimethylamino-propane hydrochloride. After a 1.3 h stirring at 75° C. (oil bath temperature) and usual work-up, purification of the crude material by silica gel (157 g) column chromatography (CH2Cl2/MeOH, 50/50) provides the title compound as a dark brown oil: ES-MS: 195.0 [M+H]+; Rf=0.13 (CH2Cl2/EtOH, 50/50).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07795288B2 |
|---|
| Source dataset | uspto-grants-2010_09 |
|---|
| ORD ID | ord-19851ee47baf42ce818468d5dd78c0f8 |
|---|
| Source note | uspto-grants-2010_09 |
|---|
