Water → HCID 68683958, compound

Participants

Reaction Conditions

Reaction Steps

0.33 g (1.5 mmol; 3.4 eq.) of dihydrated tin chloride is added to 250 mg (0.43 mmol) of N,N′-(oxydiethane-2,1-diyl)bis(5-methoxy-4-nitro-1,3-benzothiazole-2-carboxamide) in solution in 10 ml of concentrated hydrochloric acid. The reaction medium is maintained under stirring at 60° C. for 4 hours, then poured into iced water and neutralized with a SN soda solution. The expected product is then extracted with 3 times 25 ml of dichloromethane, then the organic phases are combined, dried over magnesium sulphate and the is solvent evaporated off under reduced pressure. 220 mg of the expected product (gross yield=98%) is obtained in the form of a yellow oil and is used in the following stage without other purification.

Provenance & Evidence