HCID 68681822, compound → HCID 59464178, compound

HRID 1713764Notes

Reaction equation

[C:1]([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:15]=[CH:14][C:13]([NH:16][C:17]([C:19]3[O:23][C:22]([NH:24][C:25]4[CH:26]=[C:27]([C:31]5[CH:36]=[CH:35][C:34]([C:37]([O:39]C)=[O:38])=[CH:33][CH:32]=5)[CH:28]=[CH:29][CH:30]=4)=[N:21][N:20]=3)=[O:18])=[CH:12][CH:11]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2].C(C1C=CC(NC2OC(C(NC3C=CC([C@H]4CC[C@H](CC(OC)=O)CC4)=CC=3)=O)=NN=2)=CC=1)C>>[C:1]([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:11]=[CH:12][C:13]([NH:16][C:17]([C:19]3[O:23][C:22]([NH:24][C:25]4[CH:26]=[C:27]([C:31]5[CH:32]=[CH:33][C:34]([C:37]([OH:39])=[O:38])=[CH:35][CH:36]=5)[CH:28]=[CH:29][CH:30]=4)=[N:21][N:20]=3)=[O:18])=[CH:14][CH:15]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2]

Participants

Reactant 2

HCID 68681822HCID 68681822, compound

HCID 178436578HCID 178436578, compound

Product 1

HCID 59464178HCID 59464178, compound

Procedure

Following the procedure of Example 357 but using methyl 3′-{[5-({[4-(4-acetylpiperazin-1-yl)phenyl]amino}carbonyl)-1,3,4-oxadiazol-2-yl]amino}biphenyl-4-carboxylate as starting material in place of methyl (trans-4-{4-[({5-[(4-ethylphenyl)amino]-1,3,4-oxadiazol-2-yl}carbonyl)amino]phenyl}cyclohexyl)acetate the title compound was obtained as a solid; 1H NMR δ 2.09 (s, 3H), 3.01-3.20 (m, 4H), 3.52-3.67 (m, 4H), 6.98 (d, 2H), 7.41 (d, 1H), 7.53 (t, 1H), 7.61-7.71 (m, 3H), 7.78 (d, 2H), 8.00 (s, 1H), 8.07 (d, 2H), 10.87 (s, 1H), 11.18 (s, 1H), 13.37 (s, 1H); MS m/e MH+ 527.

Sources & evidence

ORD record: ord-fcf8561ba6024ddb83c69e264ff88e00
Source dataset: uspto-grants-2010_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07795283B2

Reaction notes

Loading…