HCID 59464057, compound → HCID 59464118, compound

HRID 1713782Notes

Reaction equation

ClC1C=CC(OC2C=CC(NC3OC(C(NC4C=CC(N5CCC(C(O)=O)CC5)=NC=4)=O)=NN=3)=CC=2)=CC=1.[Cl:39][C:40]1[CH:78]=[CH:77][C:43]([O:44][C:45]2[CH:50]=[CH:49][C:48]([NH:51][C:52]3[O:56][C:55]([C:57]([NH:59][C:60]4[CH:61]=[CH:62][C:63]([N:66]5[CH2:71][CH2:70][CH:69]([CH2:72][C:73]([O:75]C)=[O:74])[CH2:68][CH2:67]5)=[N:64][CH:65]=4)=[O:58])=[N:54][N:53]=3)=[CH:47][CH:46]=2)=[CH:42][CH:41]=1>>[Cl:39][C:40]1[CH:41]=[CH:42][C:43]([O:44][C:45]2[CH:46]=[CH:47][C:48]([NH:51][C:52]3[O:56][C:55]([C:57]([NH:59][C:60]4[CH:61]=[CH:62][C:63]([N:66]5[CH2:71][CH2:70][CH:69]([CH2:72][C:73]([OH:75])=[O:74])[CH2:68][CH2:67]5)=[N:64][CH:65]=4)=[O:58])=[N:54][N:53]=3)=[CH:49][CH:50]=2)=[CH:77][CH:78]=1

Participants

Reactant 2

HCID 59464057HCID 59464057, compound

HCID 59464220HCID 59464220, compound

Product 1

HCID 59464118HCID 59464118, compound

Procedure

Prepared by the procedure described for 1-(5-{[(5-{[4-(4-Chlorophenoxy)phenyl]amino}-1,3,4-oxadiazol-2-yl)carbonyl]amino}pyridin-2-yl)piperidine-4-carboxylic acid (Example 637) except starting with methyl [1-(5-{[(5-{[4-(4-chlorophenoxy)phenyl]amino}-1,3,4-oxadiazol-2-yl)carbonyl]amino}pyridin-2-yl)piperidin-4-yl]acetate (Example 640).

Workup

customPrepared by the procedure

Sources & evidence

ORD record: ord-75e5619049f14abfad80133a1527f685
Source dataset: uspto-grants-2010_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07795283B2

Reaction notes

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