HCID 59464102, compound → HCID 59464127, compound

HRID 1713837Notes

Reaction equation

[CH3:1][O:2][CH2:3][C@@H:4]([O:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([N+:13]([O-])=O)[CH:8]=1)[CH3:5].COC[C@H](OC1C=C(C=CC=1)N)C>>[CH3:1][O:2][CH2:3][C@@H:4]([O:6][C:7]1[CH:8]=[C:9]([CH:10]=[CH:11][CH:12]=1)[NH2:13])[CH3:5]

Participants

Reactant 2

HCID 59464102HCID 59464102, compound

HCID 59464286HCID 59464286, compound

Product 1

HCID 59464127HCID 59464127, compound

Procedure

Reduction of 1-{[(1S)-2-Methoxy-1-methylethyl]oxy}-3-nitrobenzene following the procedure described for Intermediate 81 part (ii) gave the title compound (Intermediate 82) as oil; 1H NMR δ 1.17 (d, 3H), 3.26 (s, 3H), 3.35-3.42 (m, 1H), 3.42-3.51 (m, 1H), 4.37-4.49 (m, 1H), 4.90 (s, 2H), 6.03-6.11 (m, 1H), 6.10-6.19 (m, 2H), 6.81-6.94 (m, 1H); MS m/e MH+ 182.

Sources & evidence

ORD record: ord-30ae32fa6adf477dbb60950fa054e295
Source dataset: uspto-grants-2010_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07795283B2

Reaction notes

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