HCID 59464167, compound → HCID 59464045, compound

HRID 1713874Notes

Reaction equation

HRID 1713874 reaction equation
[NH:1](C(=O)C(NC1C=CC(N2CCOCC2)=CC=1)=O)[NH2:2].[Cl:20][C:21]1[CH:22]=[C:23]([NH:34][C:35](=[O:40])[C:36](OC)=[O:37])[CH:24]=[C:25]([Cl:33])[C:26]=1[N:27]1[CH2:32][CH2:31][O:30][CH2:29][CH2:28]1>>[Cl:20][C:21]1[CH:22]=[C:23]([NH:34][C:35](=[O:40])[C:36]([NH:1][NH2:2])=[O:37])[CH:24]=[C:25]([Cl:33])[C:26]=1[N:27]1[CH2:32][CH2:31][O:30][CH2:29][CH2:28]1

Participants

3

Reactant 2

HCID 59464167HCID 59464167, compoundHCID 59464213HCID 59464213, compound

Product 1

HCID 59464045HCID 59464045, compound

Procedure

Following the general procedure of Intermediate 18, using methyl [(3,5-dichloro-4-morpholin-4-ylphenyl)amino](oxo)acetate as starting material, the title compound (Intermediate 100) was obtained; 1H NMR δ 3.08 (4H, t), 3.67 (4H, t), 4.62 (2H, s), 7.93 (2H, s), 10.31 (1H, broad s), 10.83 (1H, broad s); MS m/e MH+ 333.

Sources & evidence

ORD record
ord-b1a554465f524016ab2f9f7e91367a60
Source dataset
uspto-grants-2010_09
Patent number
US07795283B2

Reaction notes

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