HCID 59464221, compound → HCID 59464094, compound

HRID 1713913Notes

Reaction equation

[NH:1]([C:3](=[O:24])[C:4]([NH:6][C:7]1[CH:8]=[C:9]([CH3:23])[C:10]([N:13]2[CH2:18][CH2:17][CH:16]([C:19](OC)=O)[CH2:15][CH2:14]2)=[N:11][CH:12]=1)=[O:5])[NH2:2].NC1C=CC([C@H]2CC[C@H](C(C)(C)[C:39]([O:41][CH3:42])=[O:40])CC2)=CC=1>>[NH:1]([C:3](=[O:24])[C:4]([NH:6][C:7]1[CH:8]=[C:9]([CH3:23])[C:10]([N:13]2[CH2:14][CH2:15][CH:16]([CH2:19][C:39]([O:41][CH3:42])=[O:40])[CH2:17][CH2:18]2)=[N:11][CH:12]=1)=[O:5])[NH2:2]

Participants

Reactant 2

HCID 59464221HCID 59464221, compound

HCID 178500369HCID 178500369, compound

Product 1

HCID 59464094HCID 59464094, compound

Procedure

Prepared following the method of Intermediate 111 part iv). 1H NMR δ 1.23-1.44 (m, 2H), 1.66-1.79 (m, 2H), 1.77-1.93 (m, 1H), 2.16 (s, 3H), 2.30 (d, 2H), 2.59-2.76 (m, 2H), 3.22-3.40 (m, 2H), 3.56 (s, 3H), 4.52 (s, 2H), 7.88 (d, 1H), 8.46 (d, 1H), 10.14 (s, 1H), 10.51 (s, 1H). MS m/e MH+ 350.21.

Workup

customPrepared

Sources & evidence

ORD record: ord-36d8e0a7c4484b80b67069c40a532f7c
Source dataset: uspto-grants-2010_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07795283B2

Reaction notes

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