HCID 59464298, compound → HCID 59464333, compound

HRID 1713918Notes

Reaction equation

HRID 1713918 reaction equation
[CH3:1][C:2]1([CH2:17][C:18]([O:20][CH3:21])=[O:19])[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[CH:12][C:11]([N+:14]([O-])=O)=[CH:10][N:9]=2)[CH2:4][CH2:3]1.N(C(=O)C(NC1C=CC(N2CCC(CC(OC)=O)CC2)=NC=1)=O)N>>[NH2:14][C:11]1[CH:12]=[CH:13][C:8]([N:5]2[CH2:6][CH2:7][C:2]([CH2:17][C:18]([O:20][CH3:21])=[O:19])([CH3:1])[CH2:3][CH2:4]2)=[N:9][CH:10]=1

Participants

3

Reactant 2

HCID 59464298HCID 59464298, compoundHCID 59464312HCID 59464312, compound

Product 1

HCID 59464333HCID 59464333, compound

Procedure

Prepared from methyl [4-methyl-1-(5-nitropyridin-2-yl)piperidin-4-yl]acetate following the method for Intermediate 77 stage ii). 1H NMR δ 1.01 (s, 3H), 1.41-1.45 (m, 2H), 1.52-1.58 (m, 2H), 2.30 (s, 2H), 3.12-3.19 (m, 2H), 3.34-3.38 (m, 2H), 3.58 (s, 3H), 4.52 (s, 2H), 6.62 (d, 1H), 6.89 (d, 1H), 7.58 (s, 1H); MS m/e MH+ 264.

Sources & evidence

ORD record
ord-0c7243dbd6c9407498b4ce7039c031b6
Source dataset
uspto-grants-2010_09
Patent number
US07795283B2

Reaction notes

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