反应详情

温度

25 °C

A solution (0.4 M) of methyl 1-(2-tert-butoxy-2-oxoethyl)-3-cyclohexyl-2-(4-methoxyphenyl)-1H-indole-6-carboxylate (from Step 2) in a 1:1 mixture of CH2Cl2/TFA was stirred at 25° C. for 4 h. The mixture was concentrated and the residue was triturated with Et2O to afford the title compound (95%) as a solid. 1H NMR (300 MHz, DMSO-d6, 300K) δ 1.13-1.36 (m, 3H), 1.62-1.95 (m, 7H), 2.56-2.67 (m, 1H), 3.86 (s, 3H), 3.89 (s, 3H), 4.74 (s, 2H), 7.12 (d, J 8.6, 2H), 7.28 (d, J 8.6, 2H), 7.69 (dd, J 8.5, 1.2, 1H), 7.86 (d, J 8.5, 1H), 8.02 (d, J 1.2, 1H), 12.98 (bs, 1H).

1. concentrationThe mixture was concentrated
2. customthe residue was triturated with Et2O