Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
tert-Butyl (3-aminopropyl)carbamate → N-(3-aminopropyl)-N-(4-(benzofuran-2-yl)thiazol-2-yl)thiophene-2-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | tert-Butyl (3-aminopropyl)carbamate | HCID 2735700 | — |
| 반응물 | Trifluoroacetic acid methylene chloride | HCID 21863450 | — |
| 반응물 | HCID 68407451 | HCID 68407451 | — |
| 생성물 | N-(3-aminopropyl)-N-(4-(benzofuran-2-yl)thiazol-2-yl)thiophene-2-carboxamide | HCID 68407996 | — |
반응 단계
According to the procedure in Example 19, (3-amino-propyl)carbamic acid tert-butyl ester was transformed into tert-butyl 3-(N-(4-(benzofuran-2-yl)thiazol-2-yl)thiophene-2-carboxamido)propylcarbamate, which was reacted with TFA/dichoromethane (3:2), stirred at room temperature for 30 min, concentrated in vacuo, then dissolved in MeOH and treated with 1M HCl/ether. The resulting precipitate was filtered and dried in vacuo to provide N-(3-aminopropyl)-N-(4-(benzofuran-2-yl)thiazol-2-yl)thiophene-2-carboxamide (220 mg) as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07795290B2 |
| 출처 데이터셋 | uspto-grants-2010_09 |
| ORD ID | ord-2eb6e81c8260488bb5345d6981069c9b |
| 출처 메모 | uspto-grants-2010_09 |