HCID 68508825, compound → HCID 68508758, compound

Participants

Reaction Steps

To a solution of methyl 2-[4-chloro-2-({[2-(dimethylamino)ethyl]amino}methyl)phenyl-3-cyclohexyl-1-(2-methoxy-2-oxoethyl)-1H-indole-6-carboxylate (from Step 5) in dry MeOH (0.05 M), 10% in weight of MeONa was added and the mixture stirred at RT overnight. The volume of the solution was reduced in vacuo before being diluted with EtOAc. The organic phase was washed with HCl 1 N, brine. The organic phase was dried over Na2SO4, filtered and the solvent evaporated in vacuo to afford the title compound. The crude was then used in the next step without any further purification (quant); MS (ES+) m/z 508 (M+H)+.

Provenance & Evidence